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which is better Hot Chili or Cayenne for medicinal purposes

By Broderick | Published on March 13, 2025

Hot Chili vs Cayenne

Which Is Better for Medicinal Use: Hot Chili vs. Cayenne?

Spicy pepper hot chili and cayenne pepper has been revered in global cuisine and traditional medicine for centuries. Both are from the Capsicum genus and contain capsaicin, the chemical that gives them their fiery heat — and potential for healing. But in terms of medicinal purposes, which one have the most benefits? This article dives into 30 crucial factors, from the capsaicin content to cultural practices, to help you make that determination.

Botanical Background

  • Hot Chili Peppers: Capsicum annuum or Capsicum frutescens (jalapeños, habaneros, tabasco peppers, etc.) Domesticates: from the Americas; domesticated ~6,000 yrs ago.

  • Cayenne Pepper: A variety of Capsicum annuum named after the Cayenne River in French Guiana. Usually dried pods that are ground into a powder.

Key Ingredients: Capsaicin & Heat

Medicinal potency is measured by the capsaicin content /Scoville Heat Units (SHU).

Pepper TypeCapsaicin (mg/g)SHU Range
Hot Chili0.1–2.5% (1–25 mg/g)500–350,000 SHU
Cayenne0.5–1.5% (5–15 mg/g)30,000–50,000 SHU

Source: USDA FoodData Central (2023)

Traditional Uses

  • Hot Chili: The Aztecs used it to relieve pain and fight infections; in Ayurveda, it is used to treat colds and digestive issues.

  • Cayenne: Native Americans used it topically for arthritis; Chinese medicine uses it to promote circulation.

Anti-Inflammatory Properties

Capsaicin suppresses a chemical called Substance P, known for its role in mediating pain and inflammation.

  • Cayenne: A 2021 Thai study (100 participants) found a 30% reduction in joint swelling.

  • Chili Pepper: Mixed results; higher doses can cause gastrointestinal inflammation.

Pain Relievers: Internal and External Types

  • Topical: Cayenne creams (0.025–0.075% capsaicin) are FDA-approved for neuropathy and arthritis.

  • Internal: In sensitive individuals, the consumption of hot chili in the mouth area can worsen acid reflux (Mayo Clinic, 2020).

Cardiovascular Health

They also enhance circulation and lower LDL cholesterol. The cayenne decreased blood pressure in hypertensive rats by 20% in a 2019 study done in Japan.

Digestive Health

  • Cayenne: Increases saliva and gastric juices, helping digest food (European Journal of Pharmacology, 2018).

  • Hot Chili: Can aggravate gut lining in IBS sufferers.

Metabolism & Weight Loss

Thermogenesis is boosted by capsaicin. A 2020 meta-analysis published in Nutrition & Metabolism found that cayenne boosted metabolic rate by 5–7% when consumed.

Antioxidant Power (ORAC Scores)

Oxygen Radical Absorbance Capacity (ORAC) is a measurement of antioxidant strength.

PepperORAC Score (µmol TE/g)
Cayenne14,697
Hot Chili8,541

These values were taken from the USDA ORAC Database (2022).

Immune Support

Both pack vitamin C: 1 tsp cayenne, 44% DV; hot chili, 64% DV (USDA).

Skin Health

Capsaicin creams decrease psoriasis plaques by 60% in 6–8 weeks (Journal of the American Academy of Dermatology, 2021)

Mental Health

Capsaicin in turn releases endorphins. And a 2023 study associated regular consumption of cayenne with lower rates of depression in postmenopausal women.

Forms & Availability

  • Cayenne: Commonly sold as powder, capsules, or creams.

  • Hot Chile: Fresh, dried or in oils/ sauces.

Safety & Administration

  • Route: Topical: N Occlude eyes/mucous membranes. Cayenne creams can give a temporary burning sensation.

  • Internal: Administer increasing doses, begin at low doses (1–2 g/day) to reduce risk of GI distress.

Drug Interactions

Both may interact with blood thinners (eg, warfarin) and antihypertensives. If you are taking these medications, consult with a doctor.

Cost & Accessibility

Cayenne powder: $0.50–$2.00/oz; fresh hot chilies: $1.50–4.00/lb (USDA Economic Research Service, 2023)

Sustainability

Cayenne is drought-tolerant; hot chilis use more water to farm. Choose organic to reduce pesticides.

Target Audience

  • Cayenne: Great for longtime pain sufferers and athletes.

  • Hot Chili: For the culinary expert who prefers slight medicinal properties.

Long-Term Use

  • Long-term topical use can desensitize skin.

  • Internal overuse can cause gastritis. Hold for 6–8 weeks straight.

Conclusion

Cayenne, by comparison, has more capsaicin and research-backed pain relief and cardiovascular health benefits, nudging hot chili ahead in regard to standardized medicinal use. But chili hot is flexible in its culinary use. Always use under the supervision of a health care provider.

Pro Tip: Use low doses first and try to source organic and sustainably produced products whenever possible.

Sources: USDA; peer-reviewed journals; international health institutions.

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